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                               CURRICULUM VITAE:

                                      Irene Gage, M.S., M.D.

PUBLICATIONS

Hemphill HE, Gage I, Zaller SA, Korman RZ. Prophage-mediated Production of a Bacteriocin-like Substance by SpB lysogens of Bacillus subtilis. Can
J Microbiol 26:1328-1333, 1980.

Koh HK, Gage I, Geller A Prout MN, Rogers GS, Lew RA. Two year Evaluation of Melanoma/Skin Cancer Screening in Massachusetts. Cancer
65:375-379, 1990.

Koh HK, Geller A, Miller A Caruso A, Gage I, Lew A. Who is Being Screened for Melanoma/Skin Cancer? Characteristics of Persons Screened in
Massachusetts. J Am Acad Dermatol 24:271-277, 1991.

Gage I, Recht A, Gelman R, Nixon A, Silver B, Bornstein BA, Harris JR. Long-term Outcome Following Breast-Conserving Surgery and Radiation
Therapy. Int J Radiat Oncol Biol Phys 33:245-251, 1995.

Nixon AJ, Schnitt SJ, Gage I, Gelman R, Bornstein BA, Hetelekidis S, Recht A, Silver B, Harris JR, Connolly JL. Relationship of Tumor Grade to
Other Pathologic Features and to Treatment Outcome for Patients with Early-Stage Breast Cancer Treated with Breast-Conserving Therapy. Cancer
78:1426-1431, 1996.

Wazer DE, Gage I, Homer MJ, Krosnick SH, Schmid C. Age-Related Differences in Patients with Nonpalpable Breast Carcinomas. Cancer
78:1432-1437, 1996.

Gage I, Schnitt SJ, Nixon AJ, Silver B, Recht A, Troyan SJ, Eberlein T, Love SM, Gelman R, Harris JR, Connolly JL. Pathologic Margin
Involvement and the Risk of Recurrence in Patients Treated with Breast-Conserving Therapy. Cancer 78:1921-1928, 1996.

Consensus Panel: Cervical Cancer. NIH Consensus Development Conference Statement. April 1-3 1996: 14: 1-38, 1996.

Monson J, Chin L, Nixon A, Gage I, Silver B, Recht A, Harris JR. Is Machine Energy (4-8MV) Associated with Outcome for Stage !-II Breast Cancer
Patients? Int J Radiat Oncol Biol Phys 37: 1095-1100, 1997.

Gage I, Harris JR. Radiation Therapy and Breast Cancer. Current Opinion in Oncology. 9:527-531, 1997.

Mock V, Dow KH, Meares C, Grimm PM, Dienemann JA,.Haisfield-Wolfe ME, Quitasol W, Mitchell S, Chakravarthy A, Gage I. Effects of
Exercise on Fatigue, Physical Functioning and Emotional Distress During Radiation Therapy for Breast Cancer. Oncology Nursing Forum
24:991-1000, 1997.

Gage I, Schnitt SJ, Recht A, Abner A, Come S, Shulman LN, Monson J, Silver B, Harris JR, Connolly JR. Skin Recurrences after
Breast-Conserving Therapy for Early Stage Breast Cancer. J Clin Oncol 16:480-486, 1997.

Gage I, Harris JR. Current Controversies in the Use of Breast-Conserving Therapy. Clinical Oncology Updates 1(2):1-11, 1998.

Connolly JL, Boyages J, Nixon AJ, Peiro G, Gage I, Silver B, Recht, A, Harris JR, Schnitt SJ. Predictors of Breast Recurrence after Conservative
Surgery and Radiation Therapy for Invasive Breast Cancer. Mod Pathol 11:134-139, 1998.

Gage I, Harris JR. Radiation Therapy and Breast Cancer. Current Opinion in Oncology 10513-516, 1998.

Asrari F, Gage I Radiation Therapy in the Management of Breast Cancer. Current Opinion in Oncology 1999, in press.

Mignano JE, Chakravarthy A, Dooley W, Piantadosi S, Zahurak M, Gage I. Recurrence Patterns After Mastectomy in Patients with Node-Positive
Breast Carcinoma and Extranodal Soft Tissue Extension Treated without Radiation. Cancer 1999, in press

ABSTRACTS

Gage I, Nixon AJ, Silver B, Bornstein BA, Gelman R, Recht A, Harris JR. Long-Term Outcome Following Breast-Conserving Therapy in
Early Stage Disease. Int J Radiat Oncol Biol Phys 30S:153, 1994.

Gage I, Recht A, Nixon A, Silver B, Bornstein,BA, Gelman R, Harris JR. Time Course of Recurrence Following Breast-Conserving Therapy
for Early Stage Disease. EORTC Breast Cancer Working Conference, Amsterdam 1994.

Peiro G, Schnitt SJ, Gage I, Silver B, Harris JR, Connolly JL. Treatment Outcome Following Conservative Surgery and Radiation Therapy for
Infiltrating Carcinoma with Mixed Ductal and Lobular Features: Comparison with Infiltrating Ductal and Lobular Carcinoma. Laboratory
Investigation. January 1995.

Gage I, Nixon AJ, Schnitt SJ, Recht A, Gelman R, Silver B, Connolly JL, Harris JR. Pathologic Margin Involvement and the Risk of Recurrence in
Patients Treated with Breast-Conserving Therapy. Int. J Radiat Oncol Biol Phys 32:138, 1995.

Nixon AJ, Gage I, Connolly JL, Schnitt S, Silver S, Hetelekidis S, Recht A, Harris JR. Relationship of Tumor Grade to Other Pathologic Features and
to Treatment Outcome for Patients with Early-Stage Breast Cancer Treated with Breast-Conserving Therapy. Int J Radiat Oncol Biol Phys 32:139, 1995

Gage I, Schnitt SJ, Connolly JL, Nixon AJ,, Recht A, Gelman R, Silver B, Harris, JR. Pathologic Margin Involvement after Lumpectomy and the Risk
of Recurrence After Breast-Conserving Therapy. Breast Cancer Research Treatment 37:41, 1996.

Mignano JE, Gage I, Piantadosi S, Chakravarthy A, Dooley W. Local Recurrence after Mastectomy in Patients with T3N0 Breast Carcinoma Treated
without Postoperative Irradiation.

Gage I, Schnitt SJ, Recht A, Abner A, Monson J, Silver B, Connolly JL, Harris JR. Skin Recurrence after Breast-Conserving Therapy for Early Stage
Breast Cancer. Breast Cancer Research and Treatment 41:221, 1996.

Herman M, Khadivi KO, Kleinberg L, Gage I, Abrams R. Effects of Respiration on Target and Critical Structure Positions during Treatment
Assessed with Movie-Loop Electronic Portal Imaging. Int J Radiat Oncol Biol Phys 1997

Mignano JE, Chakravarthy A, Dooley W, Piantadosi S, Zahurak M, Gage I. Recurrence Patterns After Mastectomy in Patients with Node-Positive
Breast Carcinoma and Extranodal Soft Tissue Extension Treated without Radiation. The 20th Annual San Antonio Breast Cancer Symposium
December 3-5, 1997.

Chakravarthy A, Kim CR, Gage I Is there a Role for Postoperative Radiation in Male Breast Cancer? Radiologic Society of North America, Chicago
Illinois. November 30, 1997.

Gage I, Bond S, Davidson NE, Clarke BV, McIntyre K, Fetting J, Kennedy MJ. Minimal Acute Toxicity Associated with Locoregional Radiation
Therapy Following Two High Dose Chemotherapy Regimens Supported with Autologous Marrow/Stem-Cell Transplantation in High Risk Breast Cancer
Patients ASCO Proc. 17:463, 1998.

Kennedy MJ, Bond S, Davidson NE, Clarke BV, Clarke K, McIntyre I, Gage I, Fetting J. Dose-Dense Sequential Chemotherapy Followed by
High-Dose Consolidation: A Phase I Study in women with High-Risk Node-Positive Breast Cancer ASCO Proc 17:355, 1998.

Thurman S, Gage I, Sherman M, Tchou J, Dooley W, Baker R. Axillary Involvement in Tubular Carcinoma. San Antonio Breast Cancer
Symposium December 1999.



INVITED LECTURES/SYMPOSIA

1993, "Current Issues in Breast Cancer Management". The 15th Annual Cancer Symposium, Illinois

1995, Long-Term Outcome Following Breast Conserving Therapy in Early Stage Breast Cancer Neoplastics Disorders, Johns Hopkins,
Baltimore, Maryland

1996, Southern Medical Association Panelist, Breast Cancer Management

1997, NIH Consensus Development Conference Panelist, Cervical Carcinoma

1997,American Society of Clinical Oncology Panelist, Breast Cancer Treatment, Denver , CO

1997,Frontiers in Breast Cancer- Research, Diagnosis and Therapy, Rockville, MD

1997- 1998, Susan Koman Grant Reviewer

1998, 1st National Renewals in Breast Cancer Treatment and Consensus, Ankara, Turkey

1999, Management of DCIS, Neoplastics Disorders, Johns Hopkins Hospital, Baltimore, Maryland

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                                                           CURRICULUM  VITAE:

                                                    Greg Scott Sibley, M.D

 

EDUCATION:         University of Michigan                  May 1986            B.Sc. (Honors) in Cellular

                                Ann Arbor, Michigan                                                 Molecular Biology

 

MEDICAL SCHOOL:   University of Michigan              May 1990              M.D.

                                      Ann Arbor, Michigan.

 

 

PROFESSIONAL TRAINING:

 

INTERNSHIP:   Transitional (Surgery and Medicine)

                           St. Joseph Mercy Hospital, Ann Arbor, Michigan. July 1990- June 1991.

 

RESIDENCY:     University of Chicago, Department of Radiation and Cellular Oncology.

                            July 1,1991-June 30,1994.

 

FELLOWSHIP:  American Society for Therapeutic Radiology and Oncology Research Fellowship.

                          University of Chicago, Department of Radaition and Cellular Oncology. July 1, 1994- June 30,1995

 

AWARDS:      American Society for Therapeutic Radiology and Oncology Research Fellowship Award.

                      July 1, 1994- June 30, 1995

 

BOARD CERTIFICATION:  American Board of Radiology (Radiation Oncology). 7/95

 

CERTIFICATION:  National Board of Medical Examiners Part I, II, AND III

 

APPOINTMENTS:  Associate, Department of Radiation Oncology, Duke Medical Center

                                July 10, 1995 - August 1, 1998.

 

                               Assistant Professor, Department of Radiation Oncology, Duke University Medical Center,

                               September 1, 1998 - February 26, 1999.

 

                              Sibley Memorial Hospital, Department of Radiation Ooncology, March 1, 1999 to Present

 

MEMBERSHIPS:  American Medical Association

                              American Association of Clinical Oncology

                              Cancer and Leukemia Group B Lung Cancer Committee

                              American Society For Therapeutic Radiology and Oncology

 

PATENTS:   Methods and Compositions for Viral Enhancement of Cell Killing, Serial No. 08/540, 343 (pending) D. Hallahan, R, Weichselbaum,

                     G. Sibley, B. Roizman, D. Kufe.

 

PUBLICATIONS

Refereed Journals

P. Sweeney, S. Vijayakumar, G. Sibley, M. Salehpour, L. Myrianthopoulos, S. Rubin, H. Sutton. A Comparison of CT-based Treatment Planning and Retrograde Urethrography in Determining the Prostatic Apex at Simulation. Medical Dosimetry 18:21-28, 1993.

A. Mundt, G. Sibley, S. Williams, S. Rubin, R. Heimann, H. Halpern, R. Weichselbaum. Patterns of Failure of Complete Responders Following High-Dose Chemotherapy and Autologous Bone Marrow Transplantation for Metastatic Breast Cancer: Implications for the Use of Adjuvant Radiation Therapy. Int. J. Radiat. Oncol. Biol. Phys. 30:151-60, 1994.

G. Sibley, A. Mundt, S. Goldman, J. Nachman, L. Johnson, R. Weichselbaum, D. Hallahan. The Patterns of Failure Following Total Body Irradiation and Bone Marrow Transplantation +/- Local Radiotherapy Boost for Advanced Neuroblastoma. Int. J. Radiat. Oncol. Biol. Phys. 32.1127-1135, 1995.

A. Mundt, A. Awan, G. Sibley, M. Simon, S. Rubin, B. Samuels, W. Wong, M. Beckett, S. Vijayakumar, R. Weichselbaum. Conservative Surgery and Adjuvant Radiation Therapy in the Management of Adult Soft Tissue Sarcoma of the Extremities: Clinical and Radiobiological Results. Int. J. Radiat. Oncol. Biol. Phys. 32:977-985, 1995.

  1. Mundt, G. Sibley, S. Williams, D. Hallahan, J. Nautiyal, R. Weichselbaum. Patterns of Failure Following High-Dose Chemotherapy and Autologous Bone Marrow Transplantation with Involved Field Radiotherapy for Relapsed/Refractory Hodgkin's Disease. Int. J. Radiat. Oncol. Biol. Phys. 33:261-270, 1995.

G. Sibley, A. Mundt, C. Shapiro, R. Jacobs, G. Chen, R. Weichselvaum, S. Vijayakumar. The Treatment of Stage III Nonsmall Cell Lung Cancer Using High Dose Conformal Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 33(5):1001-1007, 1995.

J. Advani, G. Sibley, P. Song, D. Hallahan, Y. Kataoko, B. Roizman, R. Weichselbaum. Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. Gene Therapy. 1997.

G. Sibley, T. Jamieson, L. Marks, M. Anscher, L. Prosnitz. Radiotherapy Alone for Medically Inoperable Stage I Non-Small Cell Lung Cancer: The Duke Experience. Int. J. Radiat. Oncol. Biol. Phys. 40:149-154, 1998.

G. Sibley. Radiotherapy for Patients with Medically Inoperable Stage I Non-Small Cell Lung Cancer: Smaller Volumes and Higher Doses. Cancer 82(3):433-438, 1998.

 

Abstracts

G. Sibley, A. Mundt, S. Vijayakumar, E. Lazaridis, R. Weichselbaum. The Treatment of Stage III Non-small Cell Lung Cancer Using High Dose Conformal Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 27 (Suppl. 1): 273-4, 1993.

A. Mundt, G. Sibley, A. Awan, S. Rubin, W. Wong, M.Beckett, R. Weichselbaum. Conservative Surgery And Adjuvant Irradiation In The Management Of Adult Soft Tissue Sarcoma: Clinical And Radiobiologic Results. Int. J. Radiat. Oncol. Biol. Phys. 27 (Suppl. 1): 293, 1993.

L. Chen, P. Sweeney, S. Vijayakumar, G. Sibley. Localization of the Prostatic Apex: A Comparison of Two Techniques. Int. J. Radiat. Oncol. Biol. Phys. 27 (Suppl. 1): 282-3, 1993.

G. Sibley, A. Mundt, S. Goldman, J. Nachman, L. Johnson, R. Weichselbaum, D. Hallahan. The Patterns of Failure Following Total Body Irradiation and Bone Marrow Transplantation +/- Local Radiotherapy Boost for Advanced Neuroblastoma. Int. J. Radiat. Oncol. Biol. Phys. 30 (Suppl. 1): 171, 1994.

A. Mundt, G. Sibley, S. Williams, D. Hallahan, R. Weichselbaum. Patterns of Failure following High Dose Chemotherapy and Autologous Bone Marrow Transplantation with Involved Field Radiotherapy for Relapsed/Refractory Hodgkin's Disease. Int. J. Radiat. Oncol. Biol. Phys. 30 (Suppl. 1): 169, 1994.

G. Sibley, D. Hallahan, J. Hyland, L. Seung, H. Mauceri, J. Chou, B Roizman, R. Weichselbaum. Evaluation of a Gene Therapy System Using a Replication Competent, Non-Neurovirulent HSV-1 Viral Vector Used in Combination With Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 32 (Suppl. 1): 173, 1995.

L. Lubich, A. Mundt, G. Sibley, D. Hallahan, J. Nautiyal, R. Weichselbaum. Early and Late Toxicity of Involved-Field Radiation Therapy in Conjunction with High-Dose Chemotherapy and Stem Cell Rescue. Int. J. Radiat. Oncol. Biol. Phys. 32 (Suppl. 1):284, 1995.

A. Mundt, G. Sibley, S. Williams, J. Nachman, D. Hallahan, S. Vijayakumar, L. Johnson, R. Weichselbaum. Patterns of Failure of Patients Undergoing High Dose Chemotherapy and Stem Cell Rescue: Implications for Use of Adjuvant Involved Field Radiotherapy. Proc. Am. Soc. Clin. Oncol. 14:925, 1995.

D. Brizel, M. Dewhirst, G. Sibley, S. Scully, J. Harrelson, R. Scher, L. Prosnitz. Tumor Hypoxia Adversely Affects the Prognosis of Carcinoma of the Head and Neck and Soft Tissue Sarcoma. Int. J. Radiat. Oncol. Biol. Phys. 36(Suppl. 1): 201, 1996.

P. Maguire, G. Sibley, S. Zhou, T. Jamieson, K. Light, L. Marks. Length of Circumferential Esophagus Within the High-Dose Radiotherapy Field Predicts for Late Esophageal Dysfunction. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):200, 1998.

T. Jamieson, G. Sibley, S. Zhou, P. Maguire, K. Light, P. Antoine, R. Clough, L. Marks, M. Anscher. Pretreatment Dosimetric Parameters Predict for the Risk of Proctitis in Prostate Cancer Patients Treated with 3-Dimensional Radiation Therapy. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):218, 1998.

S. Zhou, G. Sibley, P. Maguire, T. Jamieson, K. Light, G. Tracton, M. Anscher, L. Marks. A New Method to Display the Three Dimensional Dose Distribution for Tubular Organs. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):376, 1998.

L. Marks, M. Munley, G. Sibley, R. Clough, D. Hollis, G. Bentel, S. Zhou, J. Paulson, R. Jaczack, R. Coleman, M. Garipagaoglu. Pre-Radiation Therapy SPECT Lung Perfusion Scans are Useful in Predicting Changes in Pulmonary Function Tests in Patients with Central Mediastinal Tumors. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):333, 1998.

M. Garipagaoglu, J. Paulson, M. Munley, D. Hollis, G. Sibley, R. Clough, M. Anscher, R. Jaczack, R. Coleman, L. Marks. Factors that Impact on the Sensitivity of Lung to Radiation-Induced Injury. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):166, 1998.

M. Munley, J. Lo, G. Sibley, G. Bentel, L. Marks. A Neural Network to Predict Symptomatic Lung Injury. Int. J. Radiat. Oncol. Biol. Phys 42 (Suppl 1):173, 1998.

J. Garst, G. Sibley, J. Herndon, S. Blackwell, L. Campagna, D. Shoemaker, J. Crawford. A Phase I Dose Escalation Study of Concurrent Vinorelbine with Definitive Radiation Therapy for Inoperable Stage III Non-Small Cell Lung Cancer. Proc ASCO, 1999.

 

PRESENTATIONS

3-D Radiotherapy in the Treatment of Lung Cancer. Lung Cancer - From Primary Care to Future Care. Durham, NC, September 20, 1996.

Management of Medically Inoperable Stage I Lung Cancer. Fourth Annual Cancer Conference, Advances in Thoracic Onocology. Palm Beach, FL, February 24-26, 1997.

New Approaches in Radiotherapy for the Treatment of Lung Cancer. Annual Meeting of the North Carolina Thoracic Society. Chapel Hill, NC, April 18, 1998.

Lung Cancer Treatment: The Carolina Consortium Approach. Third International Symposium: 3-D Radiation Treatment Planning and Conformal Therapy. Chapel Hill, NC, September 1-3, 1998.

Combined Modality Therapy, Radiation or Surgery? Critical Issues in Thoracic Oncology. First Annual Co-Sponsored Duke/UNC Oncology Symposium. Pinehurst, NC, November 13-14, 1998.

 

                                                               

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