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Early Detection For Lung Cancer

A recent in the US is offering hope for why dogs are not trained to detect VOCs
testing for lung cancer. US scientists in the same manner that dogs are trained
have now developed and already tested a to detect drugs and other compounds.
prototype breath test to detect lung The prototype of this device was
cancer. This may enable doctors to detect developed by Dr Peter Mazzone of the The
lung cancer at earlier stages. Cleveland Clinic in Ohio in collaboration
The results of the US study test was with the private company ChemSensing of
published in the international journal of Champaign, Illinois. The private company
respiratory medicine Thorax. customizes Metalloporphyrins, a
In the tests, the colour testing device, chemically reactive dye family that are
which is the size of a coin and is sensitive to VOCs.
surprisingly inexpensive, had a 75 per They are working to develop an
cent success rate in detecting people inexpensive device. The only equipment
with different cancers. available to the public are mass
However, the tests were not 100 per cent spectrometers or gas chromatographs.
accurate. The device showed false These are expensive and require the
positives on people who did not have lung services of an expert to analyse the
cancer. This reduces the device's results.
effectiveness removing doctor's ability The new device resembles a 2 cm square
to start immediate treatments. key fob with a 6 by 6 pattern of coloured
The technique called a "colorimetric dots visible through the plastic casing.
sensor array" picks up the chemical Changes in the pattern of the dots
fingerprint of the breath of people with indicate the presence of VOCs in the
lung cancer that are caused by the breath based on the gas makeup of the
tumours. breath.
Cancers produce volatile organic Scientists tested 143 patients. Patients
compounds (VOCs) that are different from needed to breathe into the device for 12
normal cells. Tumours in the lungs are minutes. The test group was divided into
more likely to contain increased signs of three groups. Some patients had lung
these abnormal compounds. This increases cancer at various stages, some had other
the potential for the device to pick up a forms of respiratory illnesses like
lung cancer "fingerprint" in the breath. emphysema. The rest were healthy.
Surprisingly, dogs are able to detect The device spotted 73 per cent of the
VOCs and differentiate between people lung cancer patients and cleared 72 per
with lung cancer and healthy people. With cent of the non-lung cancer patients.
'early response' a major factor in This is not 100 per cent, but the results
survival rates, there are many who wonder are acceptable.




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