| Long-term Tamoxifen use, as widely promoted by | | | | cancer prevention. At that time it was clear that |
| oncologists for women following breast cancer, turns | | | | Tamoxifen increased leptin levels, thus provoking an |
| out to increase the risk of highly aggressive hormone | | | | increase in inflammation that causes increased cancer |
| receptor-negative breast cancer by 440%. This | | | | risk. Due to this, women on Tamoxifen are likely to |
| means that while Tamoxifen reduces the risk for less | | | | gain weight, thus inducing insulin resistance (and IGF1 |
| invasive estrogen positive cancer by 60%, it is at the | | | | confusion in breast tissue), which again leads to |
| same time putting many women in extreme peril. | | | | increased risk for another breast cancer. Tamoxifen |
| The lead researcher, Christopher Li, M.D., Ph.D., at | | | | also causes fatty liver congestion, increased risk for |
| Fred Hutchinson Cancer Research Center seemed | | | | endometrial cancer, vaginal bleeding and discharge, |
| more apologetic than anything in quotes from his | | | | major circulatory adverse events, and hot flashes. |
| press release, almost embarrassed to publish the | | | | Of course, the FDA doesn’t do anything about |
| results for fear of professional backlash. This | | | | this because they are inept at making drug |
| position reflects the extreme pressure researchers | | | | companies do the follow up safety testing required |
| find themselves in when they publish studies that | | | | by law. The FDA simply sits around until a |
| would cause almost any woman to not take | | | | catastrophe blows up in its face, and then they |
| Tamoxifen. | | | | move like a tortoise trying to cross the road – |
| Dr. Li’s fear is testament to the sickness that | | | | hoping to limit liability for the drug company involved. |
| pervades the medical community’s use of | | | | It is hard to know if the medical profession will ever |
| drugs. His study is unlikely to change any prescribing | | | | wake up to the damage they are causing in the |
| practices in America, as short-sighted doctors will | | | | name of “help.” If you are a woman taking |
| decide in their own minds that the benefits of | | | | Tamoxifen and you have gained weight or you |
| Tamoxifen outweigh the risks – even when the | | | | can’t lose weight, you need to find something |
| data says it doesn’t. In essence, his data is not | | | | else to do because the risks likely outweigh the |
| welcome. | | | | benefits. |
| In 2002, in my book Mastering Leptin, I pointed out | | | | To prevent a second cancer you must get insulin, |
| the ridiculousness of using Tamoxifen for breast | | | | leptin, and IGF1 signals working in harmony. |