| More than 500,000 Americans died from cancer in | | | | - inflammation |
| 2008, and millions more lost their battles against | | | | - free radical production. |
| cancer worldwide despite decades of research and | | | | Metastasis is the spread of a disease from one organ |
| billions of dollars invested. It would seem with such | | | | or part of an organ to another non-adjacent organ or |
| overwhelming figures that all hope for a cure is lost, | | | | part of the body. IP6 stops this spread by preventing |
| and that cancer is too powerful an opponent to be | | | | the adhesion of these cells to extra-cellular matrix |
| matched. That was until a seemingly ordinary scientist | | | | proteins. Inflammation levels are one key indicator |
| from the University of Maryland, Dr. Abulkalam | | | | used in predicting the survival rate for a cancer |
| Shamsuddin, emerged with an interesting set of | | | | patient. If too much inflammation occurs, the cells in |
| hypotheses. | | | | the body will ultimately become too mutated and |
| Shamsuddin believed that there may be, in fact, a | | | | damaged to survive. By maintaining proper stability |
| biomolecule that could be effective in fighting cancer, | | | | and inter-cell communication, IP6 halts this production. |
| particularly in the colon. This molecule, Inositol | | | | Lastly, free radicals work to damage DNA strands, |
| Hexophosphate (IP6), quickly gained following in the | | | | which allows for a greater rate of cell mutation. |
| holistic medicine community. However, it gained little | | | | Working as a powerful antioxidant, IP6 binds with the |
| traction in the mainstream markets, believed to be | | | | free radicals rendering them harmless. |
| too simplistic to have such a drastic impact. However, | | | | Specifically in the prostate, researchers found that |
| recent studies done by Shamsuddin and his team at | | | | IP6 inhibited the progression of the cancer cells in the |
| the Department of Medical and Research Technology | | | | area and was highly effective in reducing |
| and Department of Pathology at the University of | | | | adenocarcinoma. 95% of all prostate cancers are |
| Maryland School of Medicine suggest otherwise. A | | | | adenocarcinoma-based, meaning the cancer has |
| separate team at the University of Colorado Cancer | | | | developed in the lining or inner surface of the gland. |
| Center sought to see if they could provide more | | | | With a greatly reduced adenocarcinoma rate, the |
| evidence to support or disprove Shamsuddin's now | | | | cancer is much less likely to develop and spread. |
| 15-year-old beliefs. | | | | In one of the studies, primary early testing was |
| Remarkably, each team found that IP6, especially | | | | completed on rats. Rats were divided into five |
| when combined with Inositol, can help reduce and | | | | groups and fed a diet that contained 0 percent, 5 |
| prevent cancer growth. | | | | percent, 10 percent or 20 percent Kelloggs' All-Bran |
| IP6 is classified as a polyphosphorylated carbohydrate | | | | cereal; a fifth group received 0.4 percent IP6 in their |
| present in almost all plant and mammalian cells. It is | | | | drinking water; an amount equal to 20 percent bran. |
| used primarily for regulating vital cellular functions and | | | | After 29 weeks, they found that in the 5 to 20 |
| acts as an intracellular messenger for many primary | | | | percent bran cereal groups, tumor incidence |
| cellular activities. Again, seemingly unremarkable and | | | | decreased 11 to 17 percent. However, rats that were |
| ordinary, IP6 is found in particular high concentrations | | | | given IP6 in their water had an even lower incidence |
| in traditional food items such as cereal and legumes, | | | | of tumor formation. In fact, drinking IP6 seemed to |
| as just one-half cup of whole kernel corn contains a | | | | work twice as well as eating the high-bran foods. |
| whopping 650 mgs of IP6. Thus, because it is derived | | | | IP6 is not just a cancer preventative-- it has other |
| from food and not chemically engineered, IP6 has no | | | | beneficial health benefits such as inhibiting kidney |
| toxic effects in the body, even at high doses. | | | | stone formation and reducing the risk of developing |
| - Scientists had previously found that IP6 increased | | | | cardiovascular disease. In addition, further research |
| the activity of genes that control proteins in human | | | | has shown its potential for treatment of diabetes, |
| prostate cancer cells lacking functional p53, the gene | | | | depression, osteoporosis, heart disease, and even |
| that provides much cancer protection. The two | | | | Parkinson's disease. Further studies confirm that the |
| recent studies at the University of Maryland and the | | | | combination of IP-6 with Inositol yields much greater |
| University of Colorado, expanded on these findings | | | | effects than IP-6 alone. |
| and discovered that IP6 works as a cancer | | | | While the molecular mechanisms underlying this |
| preventative on several different levels. | | | | anticancer action are not still fully understood, these |
| - IP6 helps to normalize the rate of cell growth and | | | | two studies further show the potentially life-changing |
| cell physiology which helps limit malicious gene | | | | effects IP6 can offer. Even Dr. Shamsuddin admits |
| mutations and reestablish control within the cell, thus | | | | that more research needs to be done before more |
| slowing cancerous growth and existence. | | | | specific dosage recommendations are given, but he |
| - IP6 also helps enhance white blood cells in the body, | | | | stresses the importance of consuming a sufficient |
| whose primary function is to boost the natural | | | | daily dose of IP6 through a combination of |
| immune system and kill any potential threats. | | | | supplements and cereals, rice, wheat bran, and other |
| Additionally, IP6 affects two other primary cell | | | | legumes. |
| functions, apoptosis and angiogenesis. Apoptosis is | | | | Dosages suggested by Dr. Shamsuddin: |
| the orderly programmed process by which cells die | | | | - Individuals with greater risk for cancer should take |
| off naturally, a process that cancerous cells try to | | | | at least 4 grams daily as a preventative measure. |
| resist. IP6 enhances this ability, which helps the body | | | | - If you have already been diagnosed with cancer, a |
| in its fight to maintain healthy surrounding tissues. | | | | recommended dosage is a minimum 8 grams daily. |
| Angiogenesis, instead, is the process by which | | | | This will not only give you the benefits explained |
| tumors set up their own blood supply, to assure | | | | earlier, but can prove to be even more effective |
| themselves of receiving enough nutrients necessary | | | | when used in combination with other treatment |
| to grow. This assurance allows them to flourish and | | | | options such as chemotherapy. |
| spread the cancer throughout the body. IP6 has been | | | | While cancer remains a major health problem in the |
| shown to inhibit this process and by starving the | | | | United States and in other developed countries, with |
| cancerous cells, subsequently forces their death. | | | | the emergence of IP6, a hope for a cure may be |
| Furthermore, IP6 inhibits three harmful processes: | | | | closer than we think. |
| - metastasis | | | | |