Environmental Risk Factors in Breast Cancer

Much has been written about pesticides andOther Pesticides: Other pesticides including endosulfan,
pollutants as being major contributors to cancerstoxaphene and dieldrin have been implicated as
today. According to the National Toxicology Programcausing breast cancer based on animal studies, but
at the U.S. Department of Health and Humantheir contribution to human breast cancer is unclear.
Services, there are 52 chemicals known to contributeCommercial Product Chemicals: A long list of chemicals
to cancers of all kinds in humans and 176 chemicalsfound in common commercial products have been
reasonably anticipated to be human carcinogens. Lungimplicated in breast cancer. This list includes industrial
and mammary cancers are the most common typessolvents (trichloroethylene, toluene and benzene),
of cancers that are found in animal based studies ofplastic water bottles and baby bottles (bisphenol-A),
potential carcinogens. Despite this data, most expertsand polyvinyl chloride, a ubiquitous chemical found in
believe that more relevant environmental risks involvefood packaging, medical products, appliances, cars
diet, lifestyle, and factors related to a prolongedand toys. Again, the significance of their contribution
exposure to estrogens. However, a brief discussionto human breast cancer is unclear.
of some proven and unproven chemicals associatedPollutants: A very well studied group of chemicals
with breast cancer risk is worthwhile.collectively called polycyclic aromatic hydrocarbons
Smoking: Researchers from Albert Einstein College of(PAHs) have also been implicated in breast cancer.
Medicine in New York examined the associationThe most common sources of these chemicals
between cigarette smoking and incidence of breastinclude charbroiled meat, cigarette smoke, car
cancer in a cohort of women who had smoked forexhaust, and burning fuel.
up to 40 years. The women were subsequentlyRadiation exposure: Mounting evidence suggests that
followed for an average of 10.6 years. Their risk ofX-ray and gamma-ray exposure may be a significant
breast cancer was 60% higher than that of womenand causative factor, particularly if the exposure is
who had never smoked. Among those who smokedduring childhood or early adulthood. Radiation therapy
20 cigarettes or more a day for 40 years, thedone for Tuberculosis and dermatologic conditions
increased risk rose to an 83% increase.and radiation exposure from atomic bombs have
DDT: DDT and its metabolite DDE are weaklybeen proven to cause breast cancer. The most
estrogenic organochlorine pesticides that accumulateimportant factor in radiation exposure is the dose of
in the food chain and collect in human adipose tissuesradiation. This is why efforts have been made to
through the consumption of animal products. Althoughdecrease the radiation from mammograms by 10-fold.
several studies showed no link when blood DDTThe energy level of the radiation may also be
levels were checked many years after exposure, aimportant. Several epidemiologic studies have shown
recent study based on samples from blood collectedan increased risk of breast cancer among female
during perinatal periods showed that women heavilyairline attendants (1.9 fold increased risk). The likely
exposed to the pesticide DDT during childhood arecause for airline attendant's increased cancer risk is
five times as likely to develop breast cancer later inexposure to cosmic radiation (neutrons and gamma
life.rays), which have much higher energy than X-rays.