Controversies in Radiation Therapy for Breast Cancer

Non-invasive breast cancer, also known as ductaland which should be observed?
carcinoma in situ, or DCIS, is highly curable. It is mostSince the potential common side effects from
commonly detected on a screening mammogram.radiation therapy, such as a skin reaction and fatigue,
The standard of care is surgical removal, followed byare temporary and the woman's risk for developing
breast radiation therapy, in women who wish toan invasive and potentially life threatening breast
conserve their breast. The alternative is arecurrence is significant, it is prudent for women to
mastectomy. Both modalities have equal survivaltake the more aggressive approach.
outcomes. However, there has been a great deal ofCertain factors, such as the woman's age, her overall
controversy about the necessity for radiationhealth, the surgical margin (or rim of normal breast
therapy for DCIS in women who opt for breasttissue removed around the DCIS, with the wider the
conservation.margin being more favorable), and the grade of the
Proponents for radiation therapy underscore the factDCIS (low grade is much less aggressive than high
that the risk of a recurrence in the breast can be agrade and intermediate grade falls between these
more aggressive or even an invasive recurrence. Halftwo extremes), should factor into the decision
of these recurrences are due to invasive breastmaking.
cancer. The latter has the potential to spread toRadiation therapy should be strongly considered for
lymph nodes of the underarm and to other parts ofyoung women, women who have close margins,
the body. Without radiation therapy, the risk of awomen with DCIS measuring more than ½
local recurrence is approximately 20%. By addingcentimeter (cm) and/or those do not have low grade
radiation therapy, the risk of such a failure is reducedDCIS. On the other hand, studies show that even
by half. Needless to say, this is a substantial benefit.older women with DCIS measuring less than ½
The experts who do not support the routine use ofcm, who have wide margins and/or low grade DCIS,
radiation therapy for DCIS espouse that there is nobenefit from the addition of radiation therapy.
difference in long-term survival between women whoThe good news is that radiation therapy is a very
undergo radiation therapy versus those who do not.easy, painless treatment that can enable women with
A woman who is willing to accept the higher risk of aDCIS to be at low risk of having the disease return in
recurrence in the breast may be treated with surgicalthe treated breast, and peace of mind that they left
removal alone. The question then arises: whichno stone unturned.
women with DCIS should undergo radiation therapy