Breast Cancer: Hormonal Risk Factors

It is not yet fully understood what the hormonal riskthe first period and the first pregnancy. There is a lot
factors are, but there have been some interestingof speculation as to why this is so. One possible
clues. It is known that it has something to do withexplanation is that between menarche and the first
age and the menstrual cycle: the younger the womanpregnancy the breast tissue is especially sensitive to
is at her first period and the older she is when shecarcinogens (cancer promoting agents). This seems
goes to menopause, the more likely she is to getto be true. Several factors such as diet, alcohol
breast cancer. It seems that the longer a woman hasconsumption and radiation exposure all seem to have
reproductive levels of hormones, the morea greater effect on a woman's breasts between her
susceptible she is to breast cancer. If shefirst period and her first pregnancy than they do
menstruates at more than 40 years of age, shelater. Thus, the developing breast is more susceptible
seems to have a particularly high risk. If the ovariesto carcinogens than the breast that has gone
are removed early and no hormone replacement isthrough its complete hormonal development. The
given, the risk of getting breast cancer is greatlyincreased vulnerability may relate to the cells'
reduced. It is not exactly an all-cure, sadly, since itcapability of mutating up until the first pregnancy.
would also heighten the danger of osteoporosis. If aThere seems to be something about the first
woman has had a hysterectomy (removal of thepregnancy of a woman that halts the cells from
ovaries), it may or may not influence her vulnerabilitybeing able to sustain a mutation, the greater the
to breast cancer, depending upon whether thechance that they'll mutate in response to a
ovaries, as well as the uterus, are removed. If acarcinogen and in a way that develops into breast
woman still has her ovaries, her body is still goingcancer.
through hormonal cycles, even though there aren'tA factor relating to the number of menstrual cycles
any more periods.is breast-feeding. Recent findings have shown that
Pregnancy also seems to affects breast cancer risk.women who breast-feed for a long period of time,
Women who have never been pregnant appear tomore than 6 consecutive years, have a decreased
be more at risk than women who have had childrenrisk of breast cancer. In addition, women who have
before the age of 30 and women who have theirhad early pregnancies and have breast-fed have a
first pregnancies after 30 have a greater risk thandiminished risk of subsequent breast cancer. This is
women who have never been pregnant at all. Themost likely related to fewer ovulatory cycles at a
hormones of pregnancy carried to term will maturecrucial moment in the reproductive life.
the breast tissue in a young woman. The sameIt is now obvious that most studies on hormonal risk
hormones after 30 may actually stimulate breastfactors of breast cancer are still very much at the
tissue that has already been mutated. Several studiestheorizing stage: as yet, it is not known why there is
indicate that a pregnancy that ends in miscarriage orthis vulnerable time in a woman's life and why or how
abortion slightly increases breast cancer risk.internal hormones affect breast cancer.
The key seems to be the amount of time between