Breast Cancer - A Brief Historical Perspective

Right after Wilhelm Conrad Roentgen discoveredheralded, only eleven years later another NIH
x-rays at the end of the nineteenth century, radiationconsensus meeting determined that breast
was shown to become effective in treating breastpreservation with lumpectomy and radiation yielded
cancer. At about the same time, William Stewardresults equivalent to modified radical mastectomy.
Halstead, a surgeon, published his first paper on theAnother new regular was established: less was indeed
radical mastectomy. Even though Halstead carried outbetter. The trend continues. These days the
drastic surgical procedures on ladies with advancedconventional axillary dissection is being replaced by
breast cancer in an era without having antibiotics,the lesser sentinel node biopsy, with a concomitant
enough ladies survived that the Halstead radicalreduction of side effects.
mastectomy continued to become the regular ofClinical radiation trials are getting established to
care until the late 1970s. A consensus meeting of thedetermine whether limited field irradiation will be
National Institutes of Health (NIH) in 1979 determinedequivalent to whole-breast irradiation. The results will
that since rates of survival and recurrence werenot be known for perhaps ten to fifteen years, but
essentially the same for the total mastectomy andradiation oncologists are still trying to do less. Similarly,
the modified total mastectomy, the modified versionmedical oncologists have shown that women with
was preferable.cancers smaller than one centimeter, who had, by
A modified radical mastectomy is far less disfiguringpathology, no breast cancer cells within the lymph
than a total mastectomy, and has far fewer negativenodes under the arm, do not require systemic
side effects overall. Soon after the consensustherapy. They require neither chemotherapy nor
meeting, modified radical mastectomy became thehormonal manipulation.
new regular of care. Although the change was