| Tea and Cancer Prevention Tea drinking is an ancient | | | | in size in mice that were fed green and black tea (1, |
| tradition dating back 5,000 years in China and India. | | | | 2). |
| Long regarded in those cultures as an aid to good | | | | 4. What are the results of human studies? |
| health, researchers now are studying tea for possible | | | | Although tea has long been identified as an |
| use in the prevention and treatment of a variety of | | | | antioxidant in the laboratory, study results involving |
| cancers. Investigators are especially interested in the | | | | humans have been contradictory. Some |
| antioxidants-called catechins-found in tea. | | | | epidemiological studies comparing tea drinkers to |
| 1. What are antioxidants? | | | | non-tea drinkers support the claim that drinking tea |
| The human body constantly produces unstable | | | | prevents cancer; others do not. Dietary, |
| molecules called oxidants, also commonly referred to | | | | environmental, and population differences may |
| as free radicals. To become stable, oxidants steal | | | | account for these inconsistencies. |
| electrons from other molecules and, in the process, | | | | Two studies in China, where green tea is a mainstay |
| damage cell proteins and genetic material. This | | | | of the diet, resulted in promising findings. One study |
| damage may leave the cell vulnerable to cancer. | | | | involving over 18,000 men found tea drinkers were |
| Antioxidants are substances that allow the human | | | | about half as likely to develop stomach or esophageal |
| body to scavenge and seize oxidants. Like other | | | | cancer as men who drank little tea, even after |
| antioxidants, the catechins found in tea selectively | | | | adjusting for smoking and other health and diet |
| inhibit specific enzyme activities that lead to cancer. | | | | factors (3). A second study at the Beijing Dental |
| They may also target and repair DNA aberrations | | | | Hospital found consuming 3 grams of tea a day, or |
| caused by oxidants (1). | | | | about 2 cups, along with the application of a tea |
| 2. What is the level of antioxidants found in tea? | | | | extract reduced the size and proliferation of |
| All varieties of tea come from the leaves of a single | | | | leukoplakia, a precancerous oral plaque (1). |
| evergreen plant, Camellia sinensis. All tea leaves are | | | | 5. Is NCI evaluating tea? |
| picked, rolled, dried, and heated. With the additional | | | | National Cancer Institute (NCI) researchers are also |
| process of allowing the leaves to ferment and | | | | investigating the therapeutic use of green tea. One |
| oxidize, black tea is produced. Possibly because it is | | | | recently completed but unpublished NCI trial studied |
| less processed, green tea contains higher levels of | | | | the antitumor effect of green tea among prostate |
| antioxidants than black tea. | | | | cancer patients. The 42 patients drank 6 grams of |
| Although tea is consumed in a variety of ways and | | | | green tea, or about 4 cups, daily for four months. |
| varies in its chemical makeup, one study showed | | | | However, only one patient experienced a short-lived |
| steeping either green or black tea for about five | | | | improvement, and nearly 70 percent of the group |
| minutes released over 80 percent of its catechins. | | | | experienced unpleasant side effects such as nausea |
| Instant iced tea, on the other hand, contains negligible | | | | and diarrhea. The study concluded drinking green tea |
| amounts of catechins (1). | | | | has limited antitumor benefit for prostate cancer |
| 3. What are the laboratory findings? | | | | patients (5). |
| In the laboratory, studies have shown tea catechins | | | | Other ongoing NCI studies are testing green tea as a |
| act as powerful inhibitors of cancer growth in several | | | | preventive agent against skin cancer. For example, |
| ways: They scavenge oxidants before cell injuries | | | | one is investigating the protective effects of a pill |
| occur, reduce the incidence and size of chemically | | | | form of green tea against sun-induced skin damage |
| induced tumors, and inhibit the growth of tumor cells. | | | | while another explores the topical application of green |
| In studies of liver, skin and stomach cancer, | | | | tea in shrinking precancerous skin changes. |
| chemically induced tumors were shown to decrease | | | | |